Levofloxacin to Prevent Bacterial Infection in Patients with Cancer and Neutropenia

2005639 citationsJournal Articlebronze Open Access

Authors

Giampaolo Bucaneve

Alessandra Micozzi · Sapienza University of Rome

Francesco Menichetti · Ospedale Cisanello

Pietro Martino · Sapienza University of Rome

Marco Dionisi

Giovanni Martinelli

Bernardino Allione

Domenico D’Antonio · Ospedale di Santo Spirito

Maurizio Buelli

Abstract

Prophylactic treatment with levofloxacin is an effective and well-tolerated way of preventing febrile episodes and other relevant infection-related outcomes in patients with cancer and profound and protracted neutropenia. The long-term effect of this intervention on microbial resistance in the community is not known.

Topics & Keywords

Neutropenia and Cancer Infections Bacterial Identification and Susceptibility Testing Antibiotics Pharmacokinetics and Efficacy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 353, Issue 10, pp. 977-987

DOI: 10.1056/nejmoa044097

Field-Weighted Citation Impact: 15.27