Brain Metabolic Alterations in Medication-Free Patients With BipolarDisorder

2004454 citationsJournal Article

Authors

Stephen R. Dager · University of Washington

Seth D. Friedman · University of Washington

Aimee Parow · Harvard University Press

Christina M. Demopulos · Harvard University Press

Andrew L. Stoll · Harvard University Press

In Kyoon Lyoo · Seoul National University

David L. Dünner

Abstract

Gray matter lactate and Glx elevations in medication-free BD patients suggest a shift in energy redox state from oxidative phosphorylation toward glycolysis. The possibility of mitochondrial alterations underlying these findings is discussed and may provide a theoretical framework for future targeted treatment interventions.

Topics & Keywords

Bipolar Disorder and Treatment Electrolyte and hormonal disorders Advanced MRI Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 61, Issue 5, pp. 450-450

DOI: 10.1001/archpsyc.61.5.450

Field-Weighted Citation Impact: 13.68