Persistent immune activation in HIV-1 infection is associated with progression to AIDS

2003776 citationsJournal Article

Authors

Mette D. Hazenberg · Sanquin

Sigrid A. Otto · Karl Landsteiner Society

Birgit HB van Benthem

Marijke Roos · Karl Landsteiner Society

Roel A. Coutinho

Joep MA Lange · University of Amsterdam

Dörte Hamann · Karl Landsteiner Society

Maria Prins

Abstract

Increased T cell activation has predictive value for HIV-1 disease progression even before seroconversion. These data support the hypothesis that persistent hyperactivation of the immune system may lead to erosion of the naive T cell pool and CD4 T cell depletion.

Topics & Keywords

HIV Research and Treatment Immune Cell Function and Interaction HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: AIDS

Volume 17, Issue 13, pp. 1881-1888

DOI: 10.1097/00002030-200309050-00006

Field-Weighted Citation Impact: 9.33