Axl and Growth Arrest–Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

2008273 citationsJournal Article

Authors

Markus Hutterer · Max Planck Institute of Biochemistry

Pjotr Knyazev · Max Planck Institute of Biochemistry

Ariane Abate

Markus Reschke · Max Planck Institute of Biochemistry

Hans Maier · National Institute of Pathology

Nadia Stefanova

Tatjana Knyazeva · Max Planck Institute of Biochemistry

Verena Barbieri

Abstract

In human gliomas, Axl and Gas6 are frequently overexpressed in both glioma and vascular cells and predict poor prognosis in GBM patients. Our results indicate that specific targeting of the Axl/Gas6 signaling pathway may represent a potential new approach for glioma treatment.

Topics & Keywords

Phagocytosis and Immune Regulation Glioma Diagnosis and Treatment Pancreatic and Hepatic Oncology Research

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Clinical Cancer Research

Volume 14, Issue 1, pp. 130-138

DOI: 10.1158/1078-0432.ccr-07-0862

Field-Weighted Citation Impact: 4.34