Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

20091,623 citationsJournal Articlebronze Open Access

Authors

Md. Zahidunnabi Dewan · NYU Langone Health

Ashley E. Galloway · NYU Langone Health

Noriko Kawashima · NYU Langone Health

J. Keith DeWyngaert · NYU Langone Health

James S. Babb · NYU Langone Health

Silvia C. Formenti · NYU Langone Health

Sandra Demaria ·

Abstract

Fractionated but not single-dose radiotherapy induces an abscopal effect when in combination with anti-CTLA-4 antibody in two preclinical carcinoma models.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Cancer, Stress, Anesthesia, and Immune Response Immunotherapy and Immune Responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 15, Issue 17, pp. 5379-5388

DOI: 10.1158/1078-0432.ccr-09-0265

Field-Weighted Citation Impact: 8.56