Activation of Spinal NF‐κB/p65 Contributes to Peripheral Inflammation and Hyperalgesia in Rat Adjuvant‐Induced Arthritis

These findings indicate that spinal NF-κB/p65 plays an important role in the initiation and development of both peripheral inflammation and hyperalgesia. Thus, inhibition of spinal NF-κB/p65 expression may provide a potential treatment to manage painful inflammatory disorders.