Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000639 citationsJournal Articlebronze Open Access

Authors

Johan W. Jonker · Erasmus MC Cancer Institute

Abstract

Bcrp1 mediates apically directed drug transport, appears to reduce drug bioavailability, and protects fetuses against drugs. We propose that strategic application of BCRP inhibitors may thus lead to more effective oral chemotherapy with topotecan or other BCRP substrate drugs.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Cancer therapeutics and mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 92, Issue 20, pp. 1651-1656

DOI: 10.1093/jnci/92.20.1651

Field-Weighted Citation Impact: 10.62