PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver

2015221 citationsJournal Articlegreen Open Access

Authors

Annie Demers · Centre National de la Recherche Scientifique

Samaneh Samami · Centre National de la Recherche Scientifique

Benjamin Lauzier · Centre National de la Recherche Scientifique

Christine Des Rosiers · Centre National de la Recherche Scientifique

Émilienne T. Ngo Sock · Centre National de la Recherche Scientifique

Huy Ong · Centre National de la Recherche Scientifique

Abstract

Our results demonstrate an important role of PCSK9 in modulating the function of CD36 and triglyceride metabolism. PCSK9-mediated CD36 degradation may serve to limit fatty acid uptake and triglyceride accumulation in tissues, such as the liver.

Topics & Keywords

Lipoproteins and Cardiovascular Health Peroxisome Proliferator-Activated Receptors Diabetes, Cardiovascular Risks, and Lipoproteins

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 35, Issue 12, pp. 2517-2525

DOI: 10.1161/atvbaha.115.306032

Field-Weighted Citation Impact: 12.95