Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells

200857 citationsJournal Articlegold Open Access

Authors

Elisabet Selga · Universitat de Barcelona

Cristina Morales · Institut d'Investigació Biomédica de Bellvitge

Verónique Noé · Universitat de Barcelona

Miguel A. Peinado · Institut d'Investigació Biomédica de Bellvitge

Carlos J. Ciudad · Universitat de Barcelona

Abstract

We provide functional evidences indicating that caveolin 1 and E-cadherin, deregulated in MTX resistant cells, may play a critical role in cell survival and may constitute potential targets for coadjuvant therapy.

Topics & Keywords

Caveolin-1 and cellular processes Kruppel-like factors research RNA Research and Splicing

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Medical Genomics

Volume 1, Issue 1, pp. 35-35

DOI: 10.1186/1755-8794-1-35

Field-Weighted Citation Impact: 1.73