A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult

2013361 citationsJournal Articlebronze Open Access

Authors

Jonathan F. Goodwin · University of Michigan–Ann Arbor

Matthew J. Schiewer · University of Michigan–Ann Arbor

Jeffry L. Dean · Thomas Jefferson University

Randy S. Schrecengost · Thomas Jefferson University

Renée de Leeuw · University of Michigan–Ann Arbor

Sumin Han · Sidney Kimmel Cancer Center

Teng Ma

Abstract

The present study identifies for the fi rst time a positive feedback circuit linking hormone action to the DNA damage response and shows the significant impact of this process on tumor progression and therapeutic response. These provocative findings provide the foundation for development of novel nodes of therapeutic intervention for advanced disease.

Topics & Keywords

DNA Repair Mechanisms Prostate Cancer Treatment and Research PARP inhibition in cancer therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Discovery

Volume 3, Issue 11, pp. 1254-1271

DOI: 10.1158/2159-8290.cd-13-0108

Field-Weighted Citation Impact: 9.12