Serum N-Terminal Pro–Brain Natriuretic Peptide Is a Sensitive Marker of Myocardial Dysfunction in AL Amyloidosis

2003516 citationsJournal Articlebronze Open Access

Authors

Giovanni Palladini · Biotechnology Research Center

Carlo Campana · Biotechnology Research Center

Catherine Klersy · Zimmer Biomet (United States)

Alessandra Balduini · Biotechnology Research Center

Giovanbattista Vadacca · Biotechnology Research Center

Vittorio Perfetti · Ospedale Civile di Vittorio Veneto

Stefano Perlini

Abstract

NT-proBNP appeared to be the most sensitive index of myocardial dysfunction and the most powerful prognostic determinant in AL amyloidosis. It adds prognostic information for newly diagnosed patients and can be useful in designing therapeutic strategies and monitoring response. NT-proBNP is a sensitive marker of heart toxicity caused by amyloidogenic light chains.

Topics & Keywords

Amyloidosis: Diagnosis, Treatment, Outcomes Parathyroid Disorders and Treatments Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 107, Issue 19, pp. 2440-2445

DOI: 10.1161/01.cir.0000068314.02595.b2

Field-Weighted Citation Impact: 6.72