Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke

2013196 citationsJournal Articlebronze Open Access

Authors

Cindy T. J. van Velthoven · University of California, San Francisco

R. Ann Sheldon · University of California, San Francisco

Annemieke Kavelaars · University of California, San Francisco

Nikita Derugin · University of California, San Francisco

Zinaida S. Vexler · University of California, San Francisco

Hanneke L.D.M. Willemen · University of California, San Francisco

Mirjam Maas

Abstract

Intranasal administration of MSC after neonatal stroke is a promising therapy for treatment of neonatal stroke. In this experimental paradigm, MSC- and BNDF-hypersecreting MSC are equally effective in reducing ischemic brain damage.

Topics & Keywords

Neonatal and fetal brain pathology Mesenchymal stem cell research Neurogenesis and neuroplasticity mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stroke

Volume 44, Issue 5, pp. 1426-1432

DOI: 10.1161/strokeaha.111.000326

Field-Weighted Citation Impact: 27.96