Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation

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Authors

Romina Macco · San Raffaele University of Rome

Ilaria Pelizzoni · San Raffaele University of Rome

Alessandra Consonni · San Raffaele University of Rome

Ilaria Vitali · San Raffaele University of Rome

Giacomo Giacalone · San Raffaele University of Rome

Filippo Martinelli Boneschi · San Raffaele University of Rome

Franca Codazzi

Abstract

We propose the protective phenotype acquired after activation not to involve the most common astrocytic antioxidant pathway, based on the Nrf2 transcription factor, but to result from a complex change in the expression and activity of several genes involved in the control of cellular redox state.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments Trace Elements in Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 10, Issue 1, pp. 130-130

DOI: 10.1186/1742-2094-10-130

Field-Weighted Citation Impact: 2.33