Tandem Mass Spectrometric Analysis for Amino, Organic, and Fatty Acid Disorders in Newborn Dried Blood Spots

2001493 citationsJournal Articlebronze Open Access

Authors

Thomas H. Zytkovicz · Jamaica Hospital

Eileen F Fitzgerald · University of Massachusetts Chan Medical School

Deborah Marsden · Boston Children's Hospital

Cecilia Larson · Jamaica Hospital

Vivian E. Shih · Massachusetts General Hospital

Donna M. Johnson · Jamaica Hospital

Arnold W. Strauss

Abstract

In screening for 23 metabolic disorders by MS/MS, an mean positive predictive value of 8% can be achieved when using cutoffs for individual markers determined empirically on newborns.

Topics & Keywords

Metabolism and Genetic Disorders Neonatal Health and Biochemistry Amino Acid Enzymes and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 47, Issue 11, pp. 1945-1955

DOI: 10.1093/clinchem/47.11.1945

Field-Weighted Citation Impact: 14.31