Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

2012657 citationsJournal Articlebronze Open Access

Authors

Huib A.M. Kerstjens · Boehringer Ingelheim (Netherlands)

Michael Engel · Boehringer Ingelheim (Germany)

Ronald Dahl · Aarhus University Hospital

Pierluigi Paggiaro · Azienda Ospedaliera Universitaria Pisana

Ekkehard Beck · Boehringer Ingelheim (Germany)

Mark Vandewalker · Cancer Research for the Ozarks

Ralf Sigmund

Abstract

In patients with poorly controlled asthma despite the use of inhaled glucocorticoids and LABAs, the addition of tiotropium significantly increased the time to the first severe exacerbation and provided modest sustained bronchodilation. (Funded by Boehringer Ingelheim and Pfizer; ClinicalTrials.gov numbers, NCT00772538 and NCT00776984.).

Topics & Keywords

Asthma and respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) Research Respiratory and Cough-Related Research

Publication Details

Published in: New England Journal of Medicine

Volume 367, Issue 13, pp. 1198-1207

DOI: 10.1056/nejmoa1208606

Field-Weighted Citation Impact: 34.06

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Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

Authors

Abstract

Topics & Keywords

Publication Details