The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids

2008100 citationsJournal Articlebronze Open Access

Authors

Tara M. D'Eon · Boston Biomedical Research Institute

Kerry A. Pierce · Boston Biomedical Research Institute

Jeffery J. Roix · Boston Biomedical Research Institute

Andrew R. Tyler · Boston Biomedical Research Institute

Hong Chen · Boston Biomedical Research Institute

Sandra R. Teixeira · Boston Biomedical Research Institute

Abstract

Our findings suggest that insulin-resistant adipocytes fail to regulate EC metabolism and decrease intracellular EC levels in response to insulin stimulation. These novel observations offer a mechanism whereby obese insulin-resistant individuals exhibit increased concentrations of ECs.

Topics & Keywords

Cannabis and Cannabinoid Research Pancreatic function and diabetes Diet, Metabolism, and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 57, Issue 5, pp. 1262-1268

DOI: 10.2337/db07-1186

Field-Weighted Citation Impact: 10.49

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