Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

2003480 citationsJournal Article

Authors

Dan E. Berkowitz · Johns Hopkins University

Ronald D. White · Johns Hopkins University

Dechun Li · Johns Hopkins University

Khalid M. Minhas · Johns Hopkins University

Amy Cernetich · Johns Hopkins University

Soonyul Kim · Johns Hopkins University

Sean Burke ·

Abstract

These findings demonstrate that arginase modulates NOS activity, likely by regulating intracellular L-arginine availability. Arginase upregulation contributes to endothelial dysfunction of aging and may therefore be a therapeutic target.

Topics & Keywords

Nitric Oxide and Endothelin Effects Renin-Angiotensin System Studies Neutrophil, Myeloperoxidase and Oxidative Mechanisms

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Circulation

Volume 108, Issue 16, pp. 2000-2006

DOI: 10.1161/01.cir.0000092948.04444.c7

Field-Weighted Citation Impact: 8.56