Primary Sjogren syndrome

Sjgren syndrome is a systemic autoimmune disease causing secretory gland dysfunction. This leads to dryness of the main mucosal surfaces such as the mouth, eyes, nose, pharynx, larynx, and vagina. 1 Sjgren syndrome may be a serious disease, with excess mortality caused by haematological cancer. The cause of Sjgren syndrome is unknown, but factors postulated to play a role are both genetic and environmental. When sicca symptoms appear in a previously healthy person, the syndrome is classified as primary Sjgren syndrome. Sjgren syndrome associated with another underlying systemic autoimmune disorder, such as systemic lupus erythematosus, rheumatoid arthritis, or scleroderma is known as secondary or, increasingly, associated Sjgren syndrome.