Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations

2006670 citationsJournal Articlebronze Open Access

Authors

Margaret C. Thompson · Texas Children's Hospital

Christine Fuller · Texas Children's Hospital

Twala L. Hogg · St. Jude Children's Research Hospital

James Dalton · St. Jude Children's Research Hospital

David Finkelstein · Texas Children's Hospital

Ching C. Lau · Texas Children's Hospital

Murali Chintagumpala

Abstract

Genome-wide expression profiles can partition large tumor cohorts into subgroups that are enriched for specific genetic alterations. This approach may assist ultimately in the selection of patients for future clinical trials of molecular targeted therapies.

Topics & Keywords

Hedgehog Signaling Pathway Studies Epigenetics and DNA Methylation Genomics and Chromatin Dynamics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 24, Issue 12, pp. 1924-1931

DOI: 10.1200/jco.2005.04.4974

Field-Weighted Citation Impact: 11.94