Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization

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Authors

Igor V. Kizub · King's College London

Ievgen Strielkov · Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Yasin Shaifta · King's College London

Silke Becker · King's College London

Jesús Prieto‐Lloret · King's College London

Vladimir A. Snetkov · King's College London

Anatoly Soloviev

Abstract

These results imply that GJs are critically involved in the signalling pathways leading to Rho kinase-dependent Ca²⁺ sensitization during sustained HPV, but not elevation of intracellular Ca²⁺, and may explain the dependence of the former on an intact endothelium.

Topics & Keywords

Connexins and lens biology Nitric Oxide and Endothelin Effects Neuroscience of respiration and sleep

Publication Details

Published in: Cardiovascular Research

Volume 99, Issue 3, pp. 404-411

DOI: 10.1093/cvr/cvt129

Field-Weighted Citation Impact: 1.46

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Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization

Authors

Abstract

Topics & Keywords

Publication Details