Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas

2005324 citationsJournal Articlebronze Open Access

Authors

Yoshiki Murakami · University of Fukui Hospital

K Saigo · Chiba University

H Takashima · Kyoto Prefectural University of Medicine

M Minami · Kyoto Prefectural University of Medicine

T Okanoue · Kyoto Prefectural University of Medicine

C Bréchot · Institut Pasteur

P Paterlini-Bréchot · Institut Pasteur

Abstract

In 61/68 (89.7%) cases, HBV DNA was integrated into cellular genes potentially providing cell growth advantage. Identification of recurrent viral integration sites into genes of the same family allows recognition of common cell signalling pathways activated in hepatocarcinogenesis.

Topics & Keywords

Hepatitis B Virus Studies Cholangiocarcinoma and Gallbladder Cancer Studies Hepatocellular Carcinoma Treatment and Prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 54, Issue 8, pp. 1162-1168

DOI: 10.1136/gut.2004.054452

Field-Weighted Citation Impact: 9.35

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