Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus

2007822 citationsReview

Authors

Shari Bolen · Johns Hopkins University

Leonard Feldman · Johns Hopkins University

Jason L. Vassy · Johns Hopkins University

Lisa M Wilson · Johns Hopkins University

Hsin‐Chieh Yeh · Johns Hopkins University

Spyridon S Marinopoulos · Johns Hopkins University

Crystal Wiley ·

Abstract

Compared with newer, more expensive agents (thiazolidinediones, alpha-glucosidase inhibitors, and meglitinides), older agents (second-generation sulfonylureas and metformin) have similar or superior effects on glycemic control, lipids, and other intermediate end points. Large, long-term comparative studies are needed to determine the comparative effects of oral diabetes agents on hard clinical end points.

Topics & Keywords

Diabetes Treatment and Management Natural Antidiabetic Agents Studies Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Internal Medicine

Volume 147, Issue 6, pp. 386-399

DOI: 10.7326/0003-4819-147-6-200709180-00178

Field-Weighted Citation Impact: 40.31