Exosomes From Human CD34 <sup>+</sup> Stem Cells Mediate Their Proangiogenic Paracrine Activity

2011592 citationsJournal Articlebronze Open Access

Authors

Susmita Sahoo · Northwestern University

Ekaterina Klychko · Northwestern University

Tina Thorne · Northwestern University

Sol Misener · Northwestern University

Kathryn M. Schultz · Northwestern University

Meredith Millay · Northwestern University

Aiko Ito ·

Abstract

Our data demonstrate that human CD34(+) cells secrete exosomes that have independent angiogenic activity both in vitro and in vivo. CD34(+) exosomes may represent a significant component of the paracrine effect of progenitor cell transplantation for therapeutic angiogenesis.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation RNA Interference and Gene Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 109, Issue 7, pp. 724-728

DOI: 10.1161/circresaha.111.253286

Field-Weighted Citation Impact: 11.69