Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

20111,461 citationsJournal Articlegreen Open Access

Authors

Antonio Di Stasi · Baylor College of Medicine

Siok‐Keen Tey · Texas Children's Hospital

Gianpietro Dotti · Methodist Hospital

Yuriko Fujita · Texas Children's Hospital

Alana A. Kennedy‐Nasser · Houston Methodist

Caridad Martinez · Methodist Hospital

Karin Straathof ·

Abstract

The iCasp9 cell-suicide system may increase the safety of cellular therapies and expand their clinical applications. (Funded by the National Heart, Lung, and Blood Institute and the National Cancer Institute; ClinicalTrials.gov number, NCT00710892.).

Topics & Keywords

CAR-T cell therapy research Virus-based gene therapy research CRISPR and Genetic Engineering

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 365, Issue 18, pp. 1673-1683

DOI: 10.1056/nejmoa1106152

Field-Weighted Citation Impact: 38.08