CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

2012305 citationsJournal Articlegreen Open Access

Authors

Akihiko Ichikawa · Akita University

Keiji Kuba · Akita University

Masayuki Morita · Akita University

Shinsuke Chida · Akita University

Hiroyuki Tezuka · Tokyo Medical and Dental University

Hiromitsu Hara · Saga University

Takehiko Sasaki ·

Abstract

CXCL10-CXCR3 signaling appears to be a critical factor for the exacerbation of the pathology of ARDS. Thus, the CXCL10-CXCR3 axis could represent a prime therapeutic target in the treatment of the acute phase of ARDS of nonviral and viral origins.

Topics & Keywords

Respiratory Support and Mechanisms Immune Response and Inflammation Respiratory viral infections research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 187, Issue 1, pp. 65-77

DOI: 10.1164/rccm.201203-0508oc

Field-Weighted Citation Impact: 10.01