Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

2014388 citationsJournal Articlebronze Open Access

Authors

Sofie Livio · University of Maryland, Baltimore

Nancy Strockbine · Centers for Disease Control and Prevention

Sandra Panchalingam · University of Maryland, Baltimore

Sharon M. Tennant · University of Maryland, Baltimore

Eileen M. Barry · University of Maryland, Baltimore

Mark E. Marohn · University of Maryland, Baltimore

Martín Antonio

Abstract

A broad-spectrum Shigella vaccine must protect against S. sonnei and 15 S. flexneri serotypes/subserotypes. A quadrivalent vaccine with O antigens from S. sonnei, S. flexneri 2a, S. flexneri 3a, and S. flexneri 6 can provide broad direct coverage against these most common serotypes and indirect coverage against all but 1 (rare) remaining subserotype through shared S. flexneri group antigens.

Topics & Keywords

Escherichia coli research studies Viral gastroenteritis research and epidemiology Clostridium difficile and Clostridium perfringens research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 59, Issue 7, pp. 933-941

DOI: 10.1093/cid/ciu468

Field-Weighted Citation Impact: 19.72