Cell-Surface Estrogen Receptors Mediate Calcium-Dependent Nitric Oxide Release in Human Endothelia

2000170 citationsJournal Articlebronze Open Access

Authors

George B. Stefano · Stony Brook University

Vincent Prévot · Stony Brook University

Jean‐Claude Beauvillain · Beth Israel Deaconess Medical Center

Patrick Cadet · Beth Israel Deaconess Medical Center

Caterina Fimiani · Beth Israel Deaconess Medical Center

Ingeborg Welters · Beth Israel Deaconess Medical Center

Gregory L. Fricchione

Abstract

Physiological doses of estrogen immediately stimulate NO release from human endothelial cells through activation of a cell-surface estrogen receptor that is coupled to increases in intracellular calcium.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 101, Issue 13, pp. 1594-1597

DOI: 10.1161/01.cir.101.13.1594

Field-Weighted Citation Impact: 12.22