α-Synuclein Locus Triplication Causes Parkinson's Disease

20034,373 citationsJournal Article

Authors

A. B. Singleton · National Institutes of Health

Andrew Singleton · National Institutes of Health

Matthew J. Farrer · National Institutes of Health

Janel Johnson · National Institutes of Health

Andrew Singleton · National Institutes of Health

A. Singleton · National Institutes of Health

Stephen Hague ·

Abstract

Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition,

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Nuclear Receptors and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science

Volume 302, Issue 5646, pp. 841-841

DOI: 10.1126/science.1090278

Field-Weighted Citation Impact: 101.87