Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza

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Authors

Yingying Zhao · Peking University

Min Lü · China Agricultural University

Lok Ting Lau · Hai Kang Life (China)

Jie Lu · Peking University

Zifen Gao · China Agricultural University

Jinhua Liu · China Agricultural University

Albert Cheung Hoi Yu ·

Abstract

The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.

Topics & Keywords

Influenza Virus Research Studies Immune Response and Inflammation interferon and immune responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 47, Issue 12, pp. 1575-1578

DOI: 10.1086/593196

Field-Weighted Citation Impact: 2.01