Cardiac Sympathetic Dysinnervation in Diabetes

1998222 citationsJournal Article

Authors

Martin Stevens · Southern Illinois University School of Medicine

David M. Raffel · Southern Illinois University School of Medicine

Kevin C. Allman · Southern Illinois University School of Medicine

Firat Dayanikli · Southern Illinois University School of Medicine

Edward Ficaro · Southern Illinois University School of Medicine

T. Sandford · Southern Illinois University School of Medicine

Abstract

Diabetes may result in left ventricular sympathetic dysinnervation with proximal hyperinnervation complicating distal denervation. This combination could result in potentially life-threatening myocardial electrical instability and explain the enhanced cardioprotection from beta-blockade in these subjects.

Topics & Keywords

Heart Rate Variability and Autonomic Control Cardiac Health and Mental Health Cardiovascular Syncope and Autonomic Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 98, Issue 10, pp. 961-968

DOI: 10.1161/01.cir.98.10.961

Field-Weighted Citation Impact: 5.41