Ten-Year Multi-Institutional Results of Breast-Conserving Surgery and Radiotherapy in <i>BRCA1/2</i>-Associated Stage I/II Breast Cancer

IBTR risk at 10 years is similar in BRCA1/2 carriers treated with breast conservation surgery who undergo oophorectomy versus sporadic controls. As expected, CBCs are significantly increased in carriers. Although the incidence of CBCs was significantly reduced in mutation carriers who received tamoxifen, this rate remained significantly greater than in controls. Additional strategies are needed to reduce contralateral cancers in these high-risk women.