Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

20001,934 citationsJournal Articlebronze Open Access

Authors

Vincenzo Pasceri · The University of Texas System

James T. Willerson · The University of Texas System

Edward T.H. Yeh · The University of Texas System

Abstract

CRP induces adhesion molecule expression in human endothelial cells in the presence of serum. These findings support the hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of atherosclerosis.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Blood properties and coagulation Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 102, Issue 18, pp. 2165-2168

DOI: 10.1161/01.cir.102.18.2165

Field-Weighted Citation Impact: 65.55