Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator

2011208 citationsJournal Articlebronze Open Access

Authors

Brenda R. Hemmelgarn · University of Calgary

Louise Moist · London Health Sciences Centre

Charmaine E. Lok · University Health Network

Marcello Tonelli · University of Alberta

Braden Manns · Alberta Kidney Disease Network

Rachel M. Holden · Queen's University

Martine Leblanc ·

Abstract

The use of rt-PA instead of heparin once weekly, as compared with the use of heparin three times a week, as a locking solution for central venous catheters significantly reduced the incidence of catheter malfunction and bacteremia. (Current Controlled Trials number, ISRCTN35253449.).

Topics & Keywords

Central Venous Catheters and Hemodialysis Vascular Procedures and Complications Dialysis and Renal Disease Management

Publication Details

Published in: New England Journal of Medicine

Volume 364, Issue 4, pp. 303-312

DOI: 10.1056/nejmoa1011376

Field-Weighted Citation Impact: 34.02

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Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator

Authors

Abstract

Topics & Keywords

Publication Details