Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes

2008163 citationsJournal Article

Authors

Tayyeba K. Ali · Togus VA Medical Center

Azza B. El‐Remessy · Togus VA Medical Center

Abstract

Together, these data suggest that diabetes-induced peroxynitrite impairs NGF neuronal survival by nitrating TrkA receptor and enhancing p75(NTR) expression.

Topics & Keywords

Advanced Glycation End Products research Biochemical effects in animals Neurological Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 57, Issue 4, pp. 889-898

DOI: 10.2337/db07-1669

Field-Weighted Citation Impact: 7.79