A New Class of Chiral Pyrrolidine−Pyridine Conjugate Base Catalysts for Use in Asymmetric Michael Addition Reactions

2004358 citationsJournal Article

Authors

Abstract

Direct catalytic asymmetric Michael addition reactions of ketones to nitroolefins using newly developed chiral pyrrolidine-pyridine conjugate bases as catalysts are described. The desired 1,4-adducts are obtained in excellent yields with high enantio- and diastereoselectivities.

Topics & Keywords

Asymmetric Synthesis and Catalysis Asymmetric Hydrogenation and Catalysis Chemical Reaction Mechanisms

Publication Details

Published in: Journal of the American Chemical Society

Volume 126, Issue 31, pp. 9558-9559

DOI: 10.1021/ja046871g

Field-Weighted Citation Impact: 21.92

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A New Class of Chiral Pyrrolidine−Pyridine Conjugate Base Catalysts for Use in Asymmetric Michael Addition Reactions

Authors

Abstract

Topics & Keywords

Publication Details