<i>TREM2</i> Variants in Alzheimer's Disease

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Authors

Rita Guerreiro · TiGenix (Spain)

Aleksandra Wojtas · TiGenix (Spain)

José Brás · TiGenix (Spain)

Minerva M. Carrasquillo · TiGenix (Spain)

Ekaterina Rogaeva · TiGenix (Spain)

Elisa Majounie · TiGenix (Spain)

Carlos Cruchaga ·

Abstract

Heterozygous rare variants in TREM2 are associated with a significant increase in the risk of Alzheimer's disease. (Funded by Alzheimer's Research UK and others.).

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Inflammation biomarkers and pathways Neurological Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 368, Issue 2, pp. 117-127

DOI: 10.1056/nejmoa1211851

Field-Weighted Citation Impact: 99.83