Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

2010192 citationsJournal Articlebronze Open Access

Authors

Masayuki Fukata · University of Miami

Limin Shang · Mount Sinai Hospital

Rebeca Santaolalla · University of Miami

John P. Sotolongo · University of Miami

Cristhine Pastorini · University of Miami

Cecilia España · University of Miami

Ryan C. Ungaro ·

Abstract

Our results show that regulation of TLRs can affect the outcome of both acute colitis and its consequences, cancer. Targeting TLR4 and other TLRs may ultimately play a role in prevention or treatment of colitis-associated cancer.

Topics & Keywords

Immune Response and Inflammation NF-κB Signaling Pathways Helicobacter pylori-related gastroenterology studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Inflammatory Bowel Diseases

Volume 17, Issue 7, pp. 1464-1473

DOI: 10.1002/ibd.21527

Field-Weighted Citation Impact: 5.11