On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

2012106 citationsJournal Articlebronze Open Access

Authors

Owen D.M. Stechishin · University of Calgary

H. Artee Luchman · University of Calgary

Yibing Ruan · University of Calgary

Michael Blough · University of Calgary

Stephanie Nguyen · University of Calgary

John J. Kelly · University of Calgary

J. Gregory Cairncross ·

Abstract

Our study demonstrates the in vitro and in vivo efficacy of on-target JAK2/STAT3 inhibition in heterogeneous BTSC lines that closely emulate the genomic and tumorigenic characteristics of human GBM.

Topics & Keywords

Glioma Diagnosis and Treatment Cancer Research and Treatments Cancer Mechanisms and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neuro-Oncology

Volume 15, Issue 2, pp. 198-207

DOI: 10.1093/neuonc/nos302

Field-Weighted Citation Impact: 4.85