Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

20022,067 citationsJournal Article

Authors

Bodo E. Strauer · Heinrich Heine University Düsseldorf

Michael Brehm · Heinrich Heine University Düsseldorf

Tobias Zeus · Heinrich Heine University Düsseldorf

Matthias Köstering · Heinrich Heine University Düsseldorf

Anna Hernandez · Heinrich Heine University Düsseldorf

Rüdiger V. Sorg · Heinrich Heine University Düsseldorf

Gesine Kögler

Abstract

These results demonstrate for the first time that selective intracoronary transplantation of autologous, mononuclear BMCs is safe and seems to be effective under clinical conditions. The marked therapeutic effect may be attributed to BMC-associated myocardial regeneration and neovascularization.

Topics & Keywords

Mesenchymal stem cell research Tissue Engineering and Regenerative Medicine Transplantation: Methods and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 106, Issue 15, pp. 1913-1918

DOI: 10.1161/01.cir.0000034046.87607.1c

Field-Weighted Citation Impact: 79.57