Gene Expression Profiles in Paraffin-Embedded Core Biopsy Tissue Predict Response to Chemotherapy in Women With Locally Advanced Breast Cancer

2005618 citationsJournal Article

Authors

Luca Gianni · Genomic Health (United States)

Milvia Zambetti · The University of Texas MD Anderson Cancer Center

Kim Clark · Genomic Health (United States)

Joffre Baker · The University of Texas MD Anderson Cancer Center

Maureen Cronin · Genomic Health (United States)

Jenny Wu · Millennium Engineering and Integration (United States)

Gabriella Mariani

Abstract

Quantitative expression of ER-related genes, proliferation genes, and immune-related genes are strong predictors of pCR in women with locally advanced breast cancer receiving neoadjuvant anthracyclines and paclitaxel.

Topics & Keywords

Molecular Biology Techniques and Applications Breast Cancer Treatment Studies Gene expression and cancer classification

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 23, Issue 29, pp. 7265-7277

DOI: 10.1200/jco.2005.02.0818

Field-Weighted Citation Impact: 23.71