Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice

2007342 citationsJournal Articlegold Open Access

Authors

Ming Shi · Chinese Academy of Medical Sciences & Peking Union Medical College

Jing Li · Chinese Academy of Medical Sciences & Peking Union Medical College

Lianming Liao · Chinese Academy of Medical Sciences & Peking Union Medical College

Bin Chen · Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

B. Li · Institute of Physiology and Basic Medicine

Lei Chen · Institute of Physiology and Basic Medicine

Abstract

These results suggest that the SDF-1/CXCR4 axis plays an important role in the regulation of motility of Flk1+ MSC. Increasing CXCR4 expression might be a potential strategy to improve engraftment of MSC in BM and accelerate the recovery of hematopoiesis.

Topics & Keywords

Chemokine receptors and signaling Mesenchymal stem cell research RNA Interference and Gene Delivery

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Haematologica

Volume 92, Issue 7, pp. 897-904

DOI: 10.3324/haematol.10669

Field-Weighted Citation Impact: 6.90