Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors

2012889 citationsJournal Articlebronze Open Access

Authors

Claudio Anasetti · Moffitt Cancer Center

Brent R. Logan · Medical College of Wisconsin

Stephanie J. Lee · Fred Hutch Cancer Center

Edmund K. Waller · Cancer Institute (WIA)

Daniel J. Weisdorf · University of Minnesota Medical Center

John R. Wingard · University of Florida Health

Corey Cutler

Abstract

We did not detect significant survival differences between peripheral-blood stem-cell and bone marrow transplantation from unrelated donors. Exploratory analyses of secondary end points indicated that peripheral-blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduce the risk of chronic GVHD. (Funded by the National Heart, Lung, and Blood Institute-National Cancer Institute and others; ClinicalTrials.gov number, NCT00075816.).

Topics & Keywords

Hematopoietic Stem Cell Transplantation Mesenchymal stem cell research Childhood Cancer Survivors' Quality of Life

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 367, Issue 16, pp. 1487-1496

DOI: 10.1056/nejmoa1203517

Field-Weighted Citation Impact: 32.28