Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

2014287 citationsJournal Articlebronze Open Access

Authors

Hanna K. Sanoff · University of Virginia

Allison M. Deal · University of North Carolina at Chapel Hill

Janakiraman Krishnamurthy · UNC Lineberger Comprehensive Cancer Center

Chad Torrice · University of Virginia

Patrick M. Dillon · University of North Carolina at Chapel Hill

Jessica A. Sorrentino · University of Virginia

Joseph G. Ibrahim

Abstract

Adjuvant chemotherapy for breast cancer is gerontogenic, inducing cellular senescence in vivo, thereby accelerating molecular aging of hematopoietic tissues.

Topics & Keywords

Telomeres, Telomerase, and Senescence Retinoids in leukemia and cellular processes DNA Repair Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 106, Issue 4, pp. dju057-dju057

DOI: 10.1093/jnci/dju057

Field-Weighted Citation Impact: 10.76