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<i>IDH1</i>and<i>IDH2</i>Mutations in Gliomas

20095,885 citationsJournal Articlebronze Open Access

Authors

Hai Yan · Duke University

D. Williams Parsons · Cancer Genetics (United States)

Genglin Jin · Pediatric Brain Tumor Foundation

Roger E. McLendon · Pediatric Brain Tumor Foundation

B. Ahmed Rasheed · Pediatric Brain Tumor Foundation

Weishi Yuan · Center for Drug Evaluation and Research

Abstract

Mutations of NADP(+)-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of malignant gliomas.

Topics & Keywords

Glioma Diagnosis and Treatment MicroRNA in disease regulation Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 360, Issue 8, pp. 765-773

DOI: 10.1056/nejmoa0808710

Field-Weighted Citation Impact: 126.79

<i>IDH1</i>and<i>IDH2</i>Mutations in Gliomas | Researchclopedia

· Pediatric Brain Tumor Foundation

Ines Batinić‐Haberle · Pediatric Brain Tumor Foundation

Siân Jones · Howard Hughes Medical Institute

Gregory J. Riggins · Johns Hopkins University

Henry S. Friedman · Pediatric Brain Tumor Foundation

Allan H. Friedman · Pediatric Brain Tumor Foundation

David A. Reardon · Pediatric Brain Tumor Foundation

James E. Herndon

Kenneth W. Kinzler · Sidney Kimmel Cancer Center

Victor E. Velculescu · Howard Hughes Medical Institute

Bert Vogelstein · Howard Hughes Medical Institute

Darell D. Bigner · Pediatric Brain Tumor Foundation