Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury

2002481 citationsJournal Article

Authors

Wenjie Wang · The King's University

Costas Schulze · The King's University

Wilma L. Suarez‐Pinzon · The King's University

Jason R.B. Dyck · The King's University

Grzegorz Sawicki · The King's University

Richard Schulz · The King's University

Abstract

These data reveal for the first time a novel molecular mechanism by which matrix metalloproteinase-2 causes acute myocardial dysfunction after ischemia-reperfusion-injury and that matrix metalloproteinase-2 has a biological action within the cell.

Topics & Keywords

Signaling Pathways in Disease Cardiac Fibrosis and Remodeling Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 106, Issue 12, pp. 1543-1549

DOI: 10.1161/01.cir.0000028818.33488.7b

Field-Weighted Citation Impact: 5.69