Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity

2007602 citationsJournal Article

Authors

Carla M. Prado · University of Alberta

Vickie E. Baracos · University of Alberta

Linda J. McCargar · University of Alberta

Abstract

Our study shows that low LBM is a significant predictor of toxicity in female patients administered 5-FU using the convention of dosing per unit of body surface area. We conclude that variation in toxicity between females and males may be partially explained by this feature of body composition.

Topics & Keywords

Nutrition and Health in Aging Frailty in Older Adults Body Composition Measurement Techniques

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 13, Issue 11, pp. 3264-3268

DOI: 10.1158/1078-0432.ccr-06-3067

Field-Weighted Citation Impact: 5.15