Variants in the Toll‐Like Receptor Signaling Pathway and Clinical Outcomes of Malaria

2008118 citationsJournal Articlebronze Open Access

Authors

Fabiana M. S. Leoratti · Universidade de São Paulo

Lilian Farias · Universidade de São Paulo

Fabiana Alves · Fundação Oswaldo Cruz

Martha Cecília Suárez-Mútis · Fundação Oswaldo Cruz

José Rodrigues Coura · Fundação Oswaldo Cruz

Jorge Kalil · Universidade de São Paulo

Erney P. Camargo ·

Abstract

Our findings indicate that the TLR-1 and TLR-6 variants are significantly associated with mild malaria, whereas the TLR-9-1486C/T variants are associated with high parasitemia. These discoveries may bring additional understanding to the pathogenesis of malaria.

Topics & Keywords

Immune Response and Inflammation Malaria Research and Control Influenza Virus Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 198, Issue 5, pp. 772-780

DOI: 10.1086/590440

Field-Weighted Citation Impact: 2.96