Small-Animal PET of Tumors with <sup>64</sup>Cu-Labeled RGD-Bombesin Heterodimer

2009127 citationsJournal Articlebronze Open Access

Authors

Zhaofei Liu

Zibo Li · Stanford University

Qizhen Cao · Stanford University

Shuanglong Liu · Stanford University

Fan Wang · Stanford University

Xiaoyuan Chen · Stanford University

Abstract

Compared with other tracers, (64)Cu-NOTA-RGD-bombesin showed favorable in vivo kinetics and enhanced tumor uptake, which warrants its further investigation for targeting tumors that express integrin or GRPR or that coexpress integrin and GRPR for imaging and therapeutic applications. The synergistic effect of RGD-bombesin heterodimers observed in this study also encourages further investigations of novel heterodimers recognizing other cell surface receptors for tumor targeting.

Topics & Keywords

Radiopharmaceutical Chemistry and Applications Peptidase Inhibition and Analysis Neuroendocrine Tumor Research Advances

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Nuclear Medicine

Volume 50, Issue 7, pp. 1168-1177

DOI: 10.2967/jnumed.108.061739

Field-Weighted Citation Impact: 11.18