Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome

2002460 citationsJournal Article

Authors

Percy Pacora · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Tinnakorn Chaiworapongsa · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Eli Maymon · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Y. M. Kim · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Ricardo Gómez · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Bo Hyun Yoon · Seoul National University

Abstract

Fetal plasma IL-6 concentration is significantly associated with the presence of inflammatory lesions in the extraplacental membranes and umbilical cord. Fetuses with fetal plasma IL-6 > 11 pg/ml had a significantly higher rate of funisitis and/or chorionic vasculitis than fetuses with fetal plasma IL-6 < 11 pg/ml. These findings suggest that funisitis/chorionic vasculitis is the histological manifestation of the fetal inflammatory response syndrome.

Topics & Keywords

Preterm Birth and Chorioamnionitis Pregnancy-related medical research Pregnancy and preeclampsia studies

UN Sustainable Development Goals

Decent work and economic growth

Publication Details

Published in: The Journal of Maternal-Fetal & Neonatal Medicine

Volume 11, Issue 1, pp. 18-25

DOI: 10.1080/jmf.11.1.18.25

Field-Weighted Citation Impact: 9.53