Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

2009608 citationsJournal Articlebronze Open Access

Authors

Michael Weller · Heidelberg University

Jörg Felsberg · Heidelberg University

Christian Hartmann · Heidelberg University

Hilmar Berger · Heidelberg University

Joachim P. Steinbach · Heidelberg University

Johannes Schramm · Heidelberg University

Manfred Westphal ·

Abstract

Molecular changes associated with gliomagenesis do not predict response to therapy in glioblastoma patients managed according to current standards of care. MGMT promoter methylation and IDH1 mutational status allow for stratification into prognostically distinct subgroups.

Topics & Keywords

Glioma Diagnosis and Treatment Brain Metastases and Treatment Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 27, Issue 34, pp. 5743-5750

DOI: 10.1200/jco.2009.23.0805

Field-Weighted Citation Impact: 25.13